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  • Title: The mitochondrial outer membrane protein Mas22p is essential for protein import and viability of yeast.
    Author: Lithgow T, Junne T, Suda K, Gratzer S, Schatz G.
    Journal: Proc Natl Acad Sci U S A; 1994 Dec 06; 91(25):11973-7. PubMed ID: 7991567.
    Abstract:
    We have cloned the gene encoding the protein Mas22p, which spans the outer membrane of yeast mitochondria. Cells that completely lack Mas22p are inviable. The plasmid-borne MAS22 gene suppresses several defects resulting from the deletion of one or more of the mitochondrial protein import receptors. Defects of Mas20p-deficient cells are explained by the reduced level of Mas22p in these mutants. Mas22p has one acidic domain in the cytosol and a second acidic domain in the mitochondrial intermembrane space. We suggest that these domains of Mas22p on either side of the outer membrane function as a relay system for transferring the basic targeting sequences of precursor proteins into the mitochondria.
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