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  • Title: Free radical-induced double base lesions.
    Author: Box HC, Freund HG, Budzinski EE, Wallace JC, Maccubbin AE.
    Journal: Radiat Res; 1995 Jan; 141(1):91-4. PubMed ID: 7997520.
    Abstract:
    Evidence is presented for the formation of products in irradiated dinucleoside monophosphates in which both bases are damaged. The dinucleoside monophosphates d(GpT), d(GpC), d(TpG) and d(CpG) were X-irradiated in oxygenated aqueous solution. Product identification was by NMR spectroscopy. In products containing double base lesions, guanine is converted to 8-hydroxyguanine and the pyrimidine base is degraded to a formamido remnant.
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