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  • Title: Adrenomedullin, a newly discovered hypotensive peptide, is a potent bronchodilator.
    Author: Kanazawa H, Kurihara N, Hirata K, Kudoh S, Kawaguchi T, Takeda T.
    Journal: Biochem Biophys Res Commun; 1994 Nov 30; 205(1):251-4. PubMed ID: 7999032.
    Abstract:
    The present study was designed to examine the effect of adrenomedullin (AM), a novel vasorelaxant peptide originally isolated from human pheochromocytoma, on histamine- or acetylcholine-induced bronchoconstriction in anesthetized guinea pigs in vivo. AM significantly inhibited acetylcholine-induced bronchoconstriction in a dose-dependent fashion. AM also significantly inhibited histamine-induced bronchoconstriction, but 10(-10) M AM had no significant inhibitory effect on this response. We also found that AM induced a long-lasting bronchodilator response, while isoproterenol induced transient bronchodilation. These preliminary findings suggest that AM may play important roles in airway function.
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