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  • Title: Epidermal growth factor triggers the translocation of insulin-responsive glucose transporter (GLUT4).
    Author: Ishii K, Kamohara S, Hayashi H, Todaka M, Kanai F, Imanaka T, Ebina Y.
    Journal: Biochem Biophys Res Commun; 1994 Nov 30; 205(1):857-63. PubMed ID: 7999123.
    Abstract:
    In a novel cell line we developed for direct, sensitive detection of insulin-responsive glucose transporter (GLUT4) on the cell surface, we considered that insulin-activated phosphatidylinositol 3-kinase (PI 3-kinase) may be involved in the signaling pathway of insulin-stimulated GLUT4 translocation. We report here evidence that epidermal growth factor (EGF), which stimulates PI 3-kinase activity, also triggers GLUT4 translocation in Chinese hamster ovary (CHO) cells stably overexpressing the EGF receptor. The EGF-dependent GLUT4 translocation is possibly mediated by two independent pathways: one by PI 3-kinase and the other by protein kinase C (PKC); the PI 3-kinase-mediated pathway predominates. Triggering of the GLUT4 translocation is not specific for insulin, rather it may be a common property of growth factors which activate PI 3-kinase.
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