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  • Title: Juvenile pityriasis rubra pilaris associated with hypogammaglobulinaemia and furunculosis.
    Author: Castanet J, Lacour JP, Perrin C, Brun P, Ortonne JP.
    Journal: Br J Dermatol; 1994 Nov; 131(5):717-9. PubMed ID: 7999608.
    Abstract:
    We report a case of follicular keratosis with inflammatory changes, consistent with a diagnosis of atypical juvenile pityriasis rubra pilaris. An unusual feature was the occurrence of severe Staphylococcus aureus folliculitis and furunculosis, a phenomenon rarely encountered in pityriasis rubra pilaris and the other follicular keratoses. Standard antibiotic and antiseptic treatment for chronic S. aureus infection was ineffective. The patient was subsequently found to have hypogammaglobulinaemia, and treatment with human polyvalent immunoglobulin infusions was successful in eradicating the sepsis. It is therefore probable that the hypogammaglobulinaemia played a pathogenic role in the development of cutaneous sepsis.
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