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  • Title: Cloning and expression analysis of a cytochrome P-450(11 beta) cDNA in sheep.
    Author: Boon WC, Roche PJ, Hammond VE, Jeyaseelan K, Crawford RJ, Coghlan JP.
    Journal: Biochim Biophys Acta; 1995 Jan 02; 1260(1):109-12. PubMed ID: 7999785.
    Abstract:
    A full length ovine steroid 11 beta-hydroxylase (cytochrome P-450(11 beta)) cDNA clone from a sheep adrenal cortex cDNA library was isolated. Sequence analysis indicates that this cDNA clone resembles bovine P-450(11 beta) cDNA (95% nucleotide sequence homology) more closely than rat P-450(11 beta) cDNA (69% nucleotide sequence homology). Although the levels of nucleotide sequence homology of this cDNA clone to the rat P-450(11 beta) cDNA and the rat P-450aldo cDNA are similar, the putative amino acid sequence shows a closer resemblance to rat P-450aldo protein. Northern blot analysis shows that there are three sizes of transcript and they are expressed throughout the adrenal cortex.
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