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  • Title: Prophylactic efficacy of milbemycin oxime against multiple infection of dogs with Dirofilaria immitis.
    Author: Tagawa M, Hara Y, Ejima H, Hayashi Y, Kusano K.
    Journal: J Vet Med Sci; 1994 Aug; 56(4):779-80. PubMed ID: 7999910.
    Abstract:
    In order to examine the prophylactic effects of milbemycin oxime (MO) against Dirofilaria immitis infection, experiments were carried out under multiple infection with D. immitis. Ten filaria-free beagles of age 4 to 8 months were each inoculated with a total number of 480 larvae 12 times at intervals of 15 days over a period of 6 months, and MO was given monthly for the 6 months at a dose of 0.25 mg/kg. The infection rate in the medicated group of dogs was nil, this suggesting complete protection of the infection, while in the non-medicated control group it ranged from 6.5 to 14.8% (mean, 11.4%).
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