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  • Title: Detection of HPV DNA by in situ hybridization in benign, premalignant and malignant lesions of the oral mucosa.
    Author: González-Moles MA, Ruiz-Avila I, González-Moles S, Martinez I, Ceballos A, Nogales F.
    Journal: Bull Group Int Rech Sci Stomatol Odontol; 1994; 37(3-4):79-85. PubMed ID: 8000233.
    Abstract:
    Evidence has accumulated in recent years that relates certain types of human papillomaviruses (HPV) to the development of some tumors. We use in situ hybridization to study DNA from HPV 6/11, 16/18 and 31/33/35 in 6 squamous papillomas, 18 hyperkeratotic/acanthosis lesions with and without dysplasia (5 and 13 cases respectively) and 27 squamous cell carcinomas of the oral mucosa. HPV DNA was found in 66% of squamous papillomas, 38.4% of hyperkeratotic/acanthosis lesions without dysplasia, 60% of epithelial dysplasia and 37% of squamous cell carcinomas. HPV DNA 6/11 was the most common type found, and in squamous cell carcinomas HPV DNA appear more frequently in well differentiated tumors.
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