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  • Title: Technetium-99m hexamethylpropyleneamineoxime labelled leucocyte scanning in the initial diagnosis of Crohn's disease.
    Author: Malcolm PN, Bearcroft CP, Pratt PG, Rampton DS, Garvie NW.
    Journal: Br J Radiol; 1994 Oct; 67(802):964-8. PubMed ID: 8000840.
    Abstract:
    The technetium hexamethylpropyleneamineoxime labelled white cell scan (WCS) is not widely used as a screening test for Crohn's disease primarily because, though sensitive, it is perceived as being insufficiently specific. A series of 42 patients screened for Crohn's disease by this method was analysed retrospectively. The sensitivity was 100% and specificity 91%. This performance was maintained in a subgroup of these patients with very low prevalence of disease. If appropriate criteria for interpretation are used the WCS is a specific as well as a sensitive screening test for Crohn's disease.
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