These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Pharmacology of dopamine D3 receptors in the islands of Calleja of the rat using quantitative receptor autoradiography.
    Author: Hillefors-Berglund M, Von Euler G.
    Journal: Eur J Pharmacol; 1994 Aug 11; 261(1-2):179-83. PubMed ID: 8001642.
    Abstract:
    The pharmacological properties of [3H]7-hydroxy-N,N-di-n-propyl-2- aminotetralin ([3H]7-OH-DPAT) binding sites in the islands of Calleja of the rat were studied using quantitative receptor autoradiography. The KD and the Bmax values of [3H]7-OH-DPAT binding were about 1.6 nM and 100 fmol/mg protein, respectively. The rank order of potency was R(-)-propylnorapomorphine > 7-OH-DPAT approximately haloperidol > raclopride > dopamine > remoxipride. Remoxipride injected in vivo (0.03-100 mumol/kg i.p., 1 h before decapitation) did not inhibit subsequent [3H]7-OH-DPAT binding. These results indicate that the pharmacological profile of dopamine D3 receptors in the islands of Calleja of the rat resembles that obtained from cell lines or membrane preparations.
    [Abstract] [Full Text] [Related] [New Search]