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  • Title: Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome.
    Author: Quaderi NA, Meehan RR, Tate PH, Cross SH, Bird AP, Chatterjee A, Herman GE, Brown SD.
    Journal: Genomics; 1994 Aug; 22(3):648-51. PubMed ID: 8001979.
    Abstract:
    The methyl CpG binding proteins (MeCP1 and MeCP2) are a class of proteins that bind to templates containing symmetrically methylated CpGs. Using an interspecific backcross segregating a number of X-linked markers, we have localized the Mecp2 gene in mouse to the X chromosome close to the microsatellite marker DXMit1. Detailed physical mapping utilizing an available YAC contig encompassing the DXMit1 locus has localized the Mecp2 gene to a 40-kb region between the L1cam and the Rsvp loci, indicating the probable position of a homologue on the human X chromosome.
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