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  • Title: Isolation and characterization of new 18-membered macrolides FD-891 and FD-892.
    Author: Seki-Asano M, Okazaki T, Yamagishi M, Sakai N, Hanada K, Mizoue K.
    Journal: J Antibiot (Tokyo); 1994 Nov; 47(11):1226-33. PubMed ID: 8002384.
    Abstract:
    New 18-membered macrolides FD-891 and FD-892 were discovered from the fermentation broth of Streptomyces graminofaciens A-8890 isolated from a soil sample collected at Yamanashi prefecture Japan. They induce morphological changes of HL-60 cells at low concentration below IC50s and have cytocidal activity against in vitro tumor cell lines. FD-891 showed 2 approximately 7 times stronger activity than doxorubicin whereas FD-892 was 20 approximately 100 fold weaker than FD-891 and doxorubicin.
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