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Title: Aldecalmycin, a new antimicrobial antibiotic from Streptomyces. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. Author: Sawa R, Takahashi Y, Itoh S, Shimanaka K, Kinoshita N, Homma Y, Hamada M, Sawa T, Naganawa H, Takeuchi T. Journal: J Antibiot (Tokyo); 1994 Nov; 47(11):1266-72. PubMed ID: 8002389. Abstract: A new antibiotic, aldecalmycin, has been discovered in the culture broth of Streptomyces sp. MJ147-72F6. Aldecalmycin was purified by solvent extraction, Diaion HP-20 chromatography, silica gel chromatography, Sephadex LH-20 chromatography, HPLC and centrifugal partition chromatography. The 1H and 13C NMR spectra of aldecalmycin showed the presence of keto-enol tautomers. Aldecalmycin is equipotent in inhibiting the growth of sensitive and methicillin-resistant Staphylococcus aureus (MRSA).[Abstract] [Full Text] [Related] [New Search]