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  • Title: Synthesis of 1-methyl-2,3-dimethyl-N(isopropyl)carbamates-4,5-dihydro-7-R'- 8-R-1H-benzo[g]indoles and evaluation of in vitro anticancer activity.
    Author: Pinna GA, Pirisi MA, Paglietti G.
    Journal: Farmaco; 1994 Feb; 49(2):121-6. PubMed ID: 8003180.
    Abstract:
    The synthesis of 7-mono or 7,8-disubstituted 4,5-dihydro-1-methyl-1H- benzo[g]indoles bearing a methyl-N-isopropylcarbamate group in position 2 or 2,3 of the pyrrole ring is described, in order to evaluate in vitro, anticancer activity. The preliminary results of this screening at the NCI of Bethesda showed a certain cellular subpanel selectivity between 10(-5) and 10(-4) molar concentrations.
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