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  • Title: New active analogues of Cucurbita maxima trypsin inhibitor III (CMTI-III) modified in the non-contact region.
    Author: Rózycki J, Kupryszewski G, Rolka K, Ragnarsson U, Zbyryt T, Krokoszyńska I, Wilusz T.
    Journal: Biol Chem Hoppe Seyler; 1994 Jan; 375(1):21-3. PubMed ID: 8003251.
    Abstract:
    Four new analogues of trypsin inhibitor CMTI-III(3-28) = [desArg1,desVal2,desGly29]CMTI-III which was recently shown to be fully active, were synthesized by the solid-phase method. The introduction of glycine in position 9 (peptide 1) and Gly-Pro-Gly (peptide 2) and Gly-Pro-Asn (peptide 3) in the regions 17-19 and 23-25, respectively, did not change the antitrypsin activity of all modified peptides. All of these substitutions are presumed to be outside the trypsin-binding loop as judged from the X-ray structure of the complex between beta-trypsin and the related inhibitor CMTI-I. Also the fourth analogue which was substituted in all the positions mentioned, exhibited the full activity.
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