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  • Title: [Hyperparathyroidism due to parathyroid carcinoma located in the mediastinum].
    Author: Boddi W, Nozzoli C, Francois C, Amorosi A, Grifoni S, Morettini A, Olivotto J, Berni G.
    Journal: Ann Ital Med Int; 1994; 9(1):32-4. PubMed ID: 8003390.
    Abstract:
    Parathyroid gland carcinoma is a rare cause of primary hyperparathyroidism. The authors discuss the case of a 56-year-old man who presented with hypercalcemia and multiple bone lesions suggestive of tumor metastases. Laboratory and radiological investigations revealed primary hyperparathyroidism in a patient with evidence of osteitis fibrosa cystica, sustained by carcinoma of a mediastinal parathyroid gland. Early titration of parathyroid hormone (PTH) levels in all patients with hypercalcemia of unclear cause is important for early diagnosis of cases that are tumor-sustained and prevention of the most severe complications. The role of immunostaining with anti-PTH antibodies in demonstrating parathyroid gland tissue in ectopic and/or non-functioning primary tumors, as well as metastases, is also discussed.
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