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  • Title: Differential regulation of paired-pulse plasticity following LTP in the dentate gyrus.
    Author: Christie BR, Abraham WC.
    Journal: Neuroreport; 1994 Jan 12; 5(4):385-8. PubMed ID: 8003660.
    Abstract:
    The mechanisms underlying the expression of long-term synaptic potentiation (LTP) in the lateral and medial perforant path inputs to the dentate gyrus were examined in pentobarbital anaesthetized rats. Lateral path LTP was accompanied by a robust, long-lasting reduction in lateral path paired-pulse facilitation (PPF). The reduction in PPF lasted for at least 1 h, and remained even after post-tetanic EPSP slopes were reduced to pre-tetanus levels. The induction of lateral path LTP and the corresponding reduction in PPF were blocked by the competitive NMDA receptor antagonist CPP. Medial path paired-pulse depression was not affected by medial path LTP. These data suggest that changes in transmitter release may contribute more to lateral path than to medial path LTP.
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