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  • Title: NGF increases [Ca2+]i in regenerating mature oligodendroglial cells.
    Author: Engel J, Althaus HH, Kristjansson GI.
    Journal: Neuroreport; 1994 Jan 12; 5(4):397-400. PubMed ID: 8003662.
    Abstract:
    The effect of NGF on [Ca2+]i of mature regenerating oligodendroglial cells was investigated by measuring fluo-3 fluorescence. NGF caused transient increases in [Ca2+]i, which could be inhibited by anti-NGF antibody. The rise in [CA2+]i was in part due to influx of extracellular Ca2+ since it was markedly attenuated in Ca2+-free solution. It also depended on release of Ca2+ from intracellular stores as tested by prior depletion with cyclopiazonic acid. These results support a role for Ca2+ in the effects of NGF on oligodendroglial cells.
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