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  • Title: Induction of ovulation in long-standing secondary amenorrhea with clomiphene citrate and repeated injections of LH-RH. Preliminary report.
    Author: Casas F, Turner D, Badano A, Mirkin A, Miechi H, Aparicio NJ, Pedroza E, Laborde N, Rosner J.
    Journal: Reproduccion; 1976; 3(1-2):141-8. PubMed ID: 800387.
    Abstract:
    Induction of ovulation in long-standing secondary amenorrhea with clomiphene citrate and repeated injections of luteinizing hormone-releasing hormone (LH-RH) in 13 women with long-standing secondary amneorrhea was assessed. All of the patients had failed to respond to treatment with clomiphene citrate plus human chorionic gonadotropin (HCG). The patients received 500-750 mg clomiphene citrate per cycle, followed by repeated injections of LH-RH (50 mcg every 90 minutes up to a total dose of 200 mcg) when the Cervical Reaction Scale reached a score of 9 or more. LH-RH treatment was initiated within 7-9 days following the completion of clomiphene therapy. LH levels showed a marked and progressive increase following each injection of LH-RH in 6 patients. The response of follicle stimulating hormone was similar, but became manifest in a shorter period of time. 7 normoestrogenic and 1 hypoestrogenic patient ovulated in response to therapy. Those patients who did not ovulate had lower LH responses than those who did. It is suggested that this therapeutic regimen may be expecially useful in patients with normoestrogenic amenorrhea.
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