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  • Title: Peripherally administered IL-1 alpha interferes with scopolamine-induced amnesia in mice.
    Author: Bianchi M, Panerai AE.
    Journal: Brain Res Cogn Brain Res; 1993 Dec; 1(4):257-9. PubMed ID: 8003924.
    Abstract:
    We studied the effects of human recombinant interleukin-1 alpha on scopolamine-induced amnesia for a passive avoidance response in the mouse. Post-training intraperitoneal administration of the cytokine (0.25 or 0.50 microgram/mouse) significantly reduced the amnesic effect of scopolamine (1.0 mg/kg i.p.). Our results indicate that peripheral interleukin-1 alpha can influence behavior and suggest the involvement of the cholinergic system in the neuromodulatory actions of this cytokine.
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