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  • Title: Synthesis and antiulcer activities of novel 2-[(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)sulfinyl]-1H- benzimidazole analogues.
    Author: Yamada S, Goto T, Shimanuki E, Narita S.
    Journal: Chem Pharm Bull (Tokyo); 1994 Mar; 42(3):718-20. PubMed ID: 8004722.
    Abstract:
    A synthetic study on a series of benzimidazole derivatives including cycloalka[b]pyridine moiety has been carried out. Among these compounds synthesized, a novel antipeptic agent with 6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine moiety (TY-11345) was found to be superior to omeprazole in (H+ + K+)-ATPase inhibitory activity and antisecretory potencies.
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