These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Regio- and stereochemistry of the dioxygenation reaction catalyzed by (S)-type lipoxygenases or by the cyclooxygenase activity of prostaglandin H synthases.
    Author: Lehmann WD.
    Journal: Free Radic Biol Med; 1994 Feb; 16(2):241-53. PubMed ID: 8005520.
    Abstract:
    Investigations on the regio- and stereochemistry of the reactions of mammalian lipoxygenases and of prostaglandin H synthases are reviewed. The results and concepts are summarized as two reaction box models. The structures of all known (S)-type lipoxygenase products of long-chain fatty acids carrying an all-cis-1,4-diene structural element including mono-, di-, and tri-hydroxyl products can be accommodated by this model. The model also provides an explanation for leukotriene formation by mammalian lipoxygenases and for the substrate specificity of lipoxygenases towards esterified fatty acids. The reaction box model for the first dioxygenation step of the cyclooxygenase activity of prostaglandin H synthase is stereochemically different from the (S)-type lipoxygenase box model.
    [Abstract] [Full Text] [Related] [New Search]