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  • Title: Platelet-activating factor (PAF) acetylhydrolase activity, type II phospholipase A2, and cytokine levels in patients with sepsis.
    Author: Endo S, Inada K, Yamashita H, Takakuwa T, Nakae H, Kasai T, Kikuchi M, Ogawa M, Uchida K, Yoshida M.
    Journal: Res Commun Chem Pathol Pharmacol; 1994 Mar; 83(3):289-95. PubMed ID: 8008978.
    Abstract:
    Platelet activating factor acetylhydrolase (PAF-AH) activity was measured in patients with sepsis, and its relationships with various cytokines and endotoxin were evaluated. PAF-AH activity was significantly higher (p = 0.0136) in 17 patients who died than 13 patients who survived. PAF-AH activity showed significant correlations with the plasma endotoxin, TNF-alpha, and IL-8 levels. These findings suggest that PAF-AH activity reflects the severity of the pathological condition.
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