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  • Title: [Activity of free radical lipid oxidation and the state of antioxidant system in patients with ischemic heart disease during myocardial revascularization].
    Author: Dubikaĭtis AIu, Koniukhova SG, Kovalev VA, Vavilova TV, Shabunevich LV, Belotserkovskiĭ MB.
    Journal: Anesteziol Reanimatol; 1994; (1):10-3. PubMed ID: 8010501.
    Abstract:
    It has been established that aortocoronary bypass surgery is characterized by imbalance in lipid peroxidation and antioxidant defense system. These changes are more pronounced in patients with the most severe forms of ischemic heart disease. During surgery the greatest intensity of lipid peroxidation is observed at the end of assisted circulation period. To prevent these disturbances it is necessary to minimize surgical trauma, reduce the duration of operation stages, refuse pronounced normobaric hyperoxia during cardiopulmonary bypass.
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