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  • Title: Basement membrane components as differential markers for mesenchymal tumors of various origin.
    Author: Nerlich AG, Haraida S, Wiest I.
    Journal: Anticancer Res; 1994; 14(2B):683-92. PubMed ID: 8010727.
    Abstract:
    We immunohistochemically analyzed the presence or absence of a pericellular basement membrane in benign and malignant soft tissue tumors of different origin--of peripheral nerve, smooth and striated muscle, fat tissue, connective tissue, blood and lymph vessels, cartilage and bone--to test the role of the expression of the BM components collagen IV, laminin, heparan sulfate proteoglycan (HSPG) and fibronectin as a differential diagnostic aid. All benign tumors revealed a BM feature corresponding to that of the normal tissue. Well differentiated sarcomas similarly showed a BM pattern close to that of the respective normal mesenchymal cells, so that these sarcomas were attributable to different histogenetic entities. Low differentiated sarcomas preserved in some, but not all, instances a typical BM pattern as well. Since the BM expression in most sarcomas of lesser degree of differentiation shows a distinctive BM pattern, we believe that the BM analysis of soft tissue sarcomas may be useful to establish a proper histogenetic classification of mesenchymal tumors.
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