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  • Title: Two regulatory elements in the 5' region of the mouse mitochondrial malate dehydrogenase gene.
    Author: Ding SH, Choudhury BK, Setoyama C, Shimada K.
    Journal: Biochem Mol Biol Int; 1994 Jan; 32(1):131-8. PubMed ID: 8012278.
    Abstract:
    We previously reported that the promoter region of the mouse mitochondrial malate dehydrogenase gene is located within the 160 base-pairs (bp) region upstream from the initiation codon, named P1, and that the -160/-131 bp region contains sequence(s) essential for the promoter activity of mitochondrial malate dehydrogenase gene. To define more precisely the regulatory mechanism of this gene, a 3' deletion analysis was performed using constructs with a constant 3' boundary at -130 bp. We obtained evidence of an additional positive regulatory element located between -393/-249 bp, named P2, the function of which can be separated from that of the P1. DNase I footprinting and gel-sift mobility experiments showed that nuclear protein binding to the P2 was not inhibited in the presence of the P1 sequences.
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