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  • Title: Increase in stimulatory G protein and glucagon-responsive adenylate cyclase activity in rat liver following partial hepatectomy.
    Author: Yagami T.
    Journal: Biochem Mol Biol Int; 1994 Jan; 32(1):159-66. PubMed ID: 8012281.
    Abstract:
    Hepatocytes from partially hepatectomized rat livers show enhanced glucagon-sensitive adenylate cyclase activity. Bmax and Kd values of glucagon receptors (GR), measured by [125I]glucagon binding to liver plasma membranes, remained unchanged following partial hepatectomy. The amount of stimulatory G proteins (Gs), quantified by cholera toxin catalyzed ADP-ribosylation, increased in parallel with an increment in glucagon-responsive adenylate cyclase activity. It is proposed that an increment of Gs is one of the factors responsible for enhancement of glucagon-sensitive adenylate cyclase activity following partial hepatectomy.
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