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  • Title: Simple and rapid high-performance liquid chromatography method for the determination of alcuronium in human plasma and urine.
    Author: Künzer T, Buzello CW, Theisohn M, Diefenbach C.
    Journal: J Chromatogr B Biomed Appl; 1994 Feb 18; 653(1):63-8. PubMed ID: 8012561.
    Abstract:
    A simple and quick HPLC assay for alcuronium is presented. Its characteristics are: precipitation of plasma proteins by acetonitrile; Spherisorb 5-CN column; acetonitrile-water (46:54, v/v) as mobile phase; flow-rate 1 ml/min; laudanosine 0.06 mg/l as internal standard with plasma; external standard with urine; UV detection at 294 nm; retention time 5.4 min; detection limit 0.025 mg/l; documented linearity: 0.025-2.0 mg/l for plasma and 1.0-80 mg/l for urine; intra- and inter-assay variability below 4%. None of nine drugs used in perioperative pharmacotherapy interfered with the assay. Satisfactory performance was exemplified in a 12-h pharmacokinetic evaluation of two patients.
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