These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Vinca alkaloids enhance the half-life of tumour ornithine decarboxylase.
    Author: Morata P, Jiménez-Mesa J, Núñez de Castro I, Sánchez-Jiménez FM.
    Journal: Cancer Lett; 1994 Jun 30; 81(2):209-13. PubMed ID: 8012939.
    Abstract:
    Naturally occurring vinca alkaloids, vincristine and vinblastine, at micromolar concentrations enhanced the ornithine decarboxylase activity in a dose-response manner in primary cultures of Ehrlich ascites carcinoma cells. After 8 h of culture in the presence or absence of vinblastine, cycloheximide was added to the medium, a 4.5-fold increase in the half-life of the ornithine decarboxylase activity was observed in vinblastine-treated cells. This effect is probably due to the inhibition of the intracellular enzyme degradation by the vinca alkaloids.
    [Abstract] [Full Text] [Related] [New Search]