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  • Title: Single-donor platelet concentrates stored in synthetic medium. In vitro and in vivo studies.
    Author: Bertolini F, Marangoni F, Loy A, Marconi M, Almini D, Rebulla P, Sirchia G.
    Journal: Int J Artif Organs; 1993 Dec; 16 Suppl 5():135-8. PubMed ID: 8013972.
    Abstract:
    Single-donor platelet concentrates (PC) were prepared in 80-120 ml plasma and stored in two polyolefin bags after addition of 250 ml plasmalyte, a simple, glucose-free synthetic medium that was previously used for platelet storage; when compared to PC stored in plasma, PC stored in plasmalyte, showed similar platelet quality, morphology and function after 5 days of storage. In vivo increments observed after transfusion of PC stored for 5 days in plasmalyte were similar to those observed after transfusion of 1-2 day old PC stored in plasma. Moreover, transfusion of 5-day old PC stored in plasmalyte was associated with correction of prolonged bleeding times in all 3 of the 3 patients evaluated. It is concluded that plasmalyte seems to be promising as a medium for single-donor PC storage.
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