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  • Title: [3H]GABA uptake and GABA localization in mucosal endocrine cells of the rat stomach and colon.
    Author: Krantis A, Tufts K, Nichols K, Morris GP.
    Journal: J Auton Nerv Syst; 1994 May; 47(3):225-32. PubMed ID: 8014381.
    Abstract:
    The aim of this study was to characterize the distribution of GABAergic cells in the rat gut mucosa. Thin and/or thick serial sections of segments of rat antrum and distal colon were treated for autoradiographic localization of sites of [3H]GABA (50 nM) high-affinity uptake, or GABA immunoreactivity. Dense accumulations of silver grains were localized to a discrete population of granulated mucosal cells. These appeared to be D-type endocrine cells. These gut regions also displayed strongly GABA-immunoreactive mucosal cells. These results confirm the presence of GABAergic cells in the rat antral mucosa, and reveal that [3H]GABA is accumulated by mucosal endocrine cells in the rat colon.
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