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  • Title: Omega-conotoxin GVIA inhibits the methylphenidate-induced but not methamphetamine-induced behavior.
    Author: Yamada K, Teraoka T, Morita S, Hasegawa T, Nabeshima T.
    Journal: Neurosci Lett; 1994 Jan 03; 165(1-2):191-4. PubMed ID: 8015724.
    Abstract:
    We investigated the effects of antagonists for omega-conotoxin GVIA (omega-CTX)-sensitive N-type voltage-sensitive calcium channels (N-channels) on methylphenidate- and methamphetamine-induced behavior. I.c.v. injection of omega-CTX or neomycin, both N-channel antagonists, caused a dose-dependent inhibition of methylphenidate-induced hypermotility in mice but failed to inhibit methamphetamine-induced hyperactivity. Further, omega-CTX inhibited the circling behavior induced by methylphenidate in rats that had kainic acid-induced unilateral striatal lesions. These results suggest that calcium influx through omega-CTX-sensitive N-channels plays an important role in methylphenidate-induced behavior.
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