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  • Title: Therapy with ursodeoxycholic acid in cholestatic liver disease.
    Author: Van de Meeberg PC, van Erpecum KJ, van Berge-Henegouwen GP.
    Journal: Scand J Gastroenterol Suppl; 1993; 200():15-20. PubMed ID: 8016564.
    Abstract:
    Ursodeoxycholic acid (UDCA) has beneficial effects on symptoms, liver biochemistry and, possibly, liver histology in primary biliary cirrhosis and other cholestatic liver diseases. UDCA may exert these beneficial effects by a direct hepatoprotective effect, by influencing the enterohepatic circulation of endogenous bile salts, by enhancing bile flow through a cholehepatic shunt mechanism or by immune modulation. In the present article, established and potential indications for UDCA are reviewed.
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