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  • Title: Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.
    Author: Steimle V, Siegrist CA, Mottet A, Lisowska-Grospierre B, Mach B.
    Journal: Science; 1994 Jul 01; 265(5168):106-9. PubMed ID: 8016643.
    Abstract:
    Major histocompatibility complex (MHC) class II genes are expressed constitutively in only a few cell types, but they can be induced in the majority of them, in particular by interferon-gamma (IFN-gamma). The MHC class II transactivator gene CIITA is defective in a form of primary MHC class II deficiency. Here it is shown that CIITA expression is controlled and induced by IFN-gamma. A functional CIITA gene is necessary for class II induction, and transfection of CIITA is sufficient to activate expression of MHC class II genes in class II-negative cells in the absence of IFN-gamma. CIITA is therefore a general regulator of both inducible and constitutive MHC class II expression.
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