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  • Title: Localised pulmonary resection for bronchiectasis in hypogammaglobulinaemic patients.
    Author: Cohen AJ, Roifman C, Brendan J, Mullen M, Reid B, Weisbrod G, Downey GP.
    Journal: Thorax; 1994 May; 49(5):509-10. PubMed ID: 8016776.
    Abstract:
    BACKGROUND: Bronchiectasis and pulmonary infections are common in patients with hypogammaglobulinaemia. Despite intravenous gammaglobulin treatment and appropriate antibiotics, a subgroup of patients remains with persistent localised pulmonary infection in segments where bronchiectasis had developed before appropriate treatment. As such localised pulmonary suppuration (segmental or lobar) may serve as a focus for progression of bronchiectasis, surgical resection of the involved segments may be considered. The outcome of pulmonary resection in four such patients is reported. RESULTS: Surgery was well tolerated except for one postoperative empyema. Information on follow up is available from 3.5 to 5 years. All patients experienced considerable reduction of symptoms including cough, sputum production, antibiotic use, and hospital admissions. CONCLUSIONS: Surgical resection of localised bronchiectatic segments should be considered in patients with hypogammaglobulinaemia with persistent localised suppuration and symptoms refractory to medical treatment.
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