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  • Title: Ultrasound guided pericardial drainage and intrapericardial instillation of mitomycin C for malignant pericardial effusion.
    Author: Lee LN, Yang PC, Chang DB, Yu CJ, Ko JC, Liaw YS, Wu RG, Luh KT.
    Journal: Thorax; 1994 Jun; 49(6):594-5. PubMed ID: 8016797.
    Abstract:
    BACKGROUND: Conservative treatment of malignant pericardial effusion by intrapericardial instillation of a sclerosing agent may be an alternative to surgery. METHODS: Twenty patients with malignant pericardial effusion were treated by ultrasound guided pericardiocentesis and the intrapericardial instillation of mitomycin C. RESULTS: Mitomycin C was effective in controlling the pericardial effusion in 70% of patients without causing side effects, except for pericardial constriction seven months later in one subject. CONCLUSIONS: Ultrasound guided intrapericardial instillation of mitomycin C is a suitable alternative in the management of malignant pericardial effusion.
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