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  • Title: [Prevention of duodenal ulcer recurrence with penicillin].
    Author: Rune SJ, Justesen T, Hansen JM, Jensen TG, Eriksen J, Thomsen OO, Scheibel JH, Bonnevie O, Bremmelgaard A, Vilien M.
    Journal: Ugeskr Laeger; 1994 Apr 11; 156(15):2211-3. PubMed ID: 8016944.
    Abstract:
    The aim of this study was to test the hypothesis that infection with Helicobacter pylori is essential for recurrence of duodenal ulcer. We performed a randomized controlled trial of the relapse rate of duodenal ulcer during 12 weeks treatment with penicillin V or placebo in 170 out-patients from five centres. The relapse rate was 9% during treatment with penicillin and 50% with placebo, P < 0.0001. It is concluded that infection with penicillin-sensitive bacteria, i.e. H. pylori, plays an important role for recurrence of duodenal ulcer disease. Penicillin V suppresses this infection but does not eradicate it.
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