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  • Title: Production of 26-deoxymonensins A and B by Streptomyces cinnamonensis in the presence of Metyrapone.
    Author: Pospísil S, Sedmera P, Havlícek V, Tax J.
    Journal: Appl Environ Microbiol; 1994 May; 60(5):1561-4. PubMed ID: 8017935.
    Abstract:
    Metyrapone, a potent cytochrome P-450 inhibitor, added at 9 mM to a submerged culture of Streptomyces cinnamonensis caused partial inhibition of total monensin biosynthesis and coproduction of new metabolites, 26-deoxymonensins A and B. The latter was isolated as its 25-O-methyl derivative. Metyrapone was simultaneously reduced to metyrapol. All of these compounds were identified by nuclear magnetic resonance spectroscopy and mass spectrometry.
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