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  • Title: Attainment of normal height in severe juvenile hypothyroidism.
    Author: Minamitani K, Murata A, Ohnishi H, Wataki K, Yasuda T, Niimi H.
    Journal: Arch Dis Child; 1994 May; 70(5):429-30; discussion 430-1. PubMed ID: 8017967.
    Abstract:
    Prolonged juvenile hypothyroidism results in a permanent loss in height that is related to the duration of thyroxine deficiency before adequate thyroxine replacement treatment. A 13 year old girl with severe juvenile hypothyroidism was studied prospectively. She had an undetectable serum thyroxine concentration, a height SD score of -6.6 SD, and a bone age of 5.8 years. The enlarged pituitary gland involuted with thyroxine treatment to produce an empty sella. In addition to thyroxine the girl was treated with a gonadotrophin releasing hormone agonist to avoid the progression of puberty for 18 months and with growth hormone to achieve normal adult height.
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