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  • Title: Chronic allograft rejection: an update.
    Author: Häyry P.
    Journal: Clin Transplant; 1994 Apr; 8(2 Pt 2):160-1. PubMed ID: 8019031.
    Abstract:
    The etiology of chronic rejection is most probably multifactorial. The common feature in all organ allografts undergoing chronic rejection is persistent perivascular inflammation and a concentric generalized arteriosclerosis affecting all first and second order intramural arteries. A hypothesis is presented that low-grade damage to endothelium induces the secretion of growth factors which, in turn, are responsible for smooth muscle cell replication and their influx into intima.
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