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  • Title: Increased secretion of latent elastase activity following contact between human skin fibroblasts and elastin derived peptides.
    Author: Landeau JM, Pellat B, Hornebeck W.
    Journal: Cell Biol Int; 1994 Feb; 18(2):111-7. PubMed ID: 8019482.
    Abstract:
    Elastin-derived peptides were previously shown to influence human skin fibroblasts (HSF) chemotaxis and proliferation (Ghuysen et al., 1992). We report here that culturing HSF on kappa-elastin (kappa E) but not onto fibronectin (FN) enhanced the secretion of latent elastinolytic activity. The proteinase involved was identified as the 72 kDa gelatinase A. Moreover, HSF-kappa E as well as HSF-FN interactions modulated the secretions of Il1 induced expressions of elastinolytic activities.
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