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  • Title: The decreased transfer of arachidonic acid from triglycerides to phospholipids during proliferation of a human gastric tumor (HGT) cell line is not linked to modification of membrane fluidity.
    Author: Najid A, Es-Saady D, Denizot Y.
    Journal: Cancer Lett; 1994 May 16; 79(2):189-92. PubMed ID: 8019978.
    Abstract:
    Prelabeling-chase experiments with [14C]arachidonic acid in human cancer gastric cells (HGT) indicated a preferential incorporation of arachidonic acid into triglycerides followed by a transfer to phospholipids. This phenomenon was quicker using cells in log phase growth than in quiescent phase and was not linked to modification of HGT membrane fluidity assessed by the fluorescence polarization of the 1,6-diphenyl hexatriene probe. By contrast, growing cells in a medium enriched with oleic or linoleic acids increase plasma membrane fluidity. The importance of the site of arachidonic incorporation in HGT lipid is discussed.
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