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  • Title: [Hematopoietic stem cells (CFUc) in athymic mice. I. The level of early and late hematopoietic precursors in the bone marrow of thymectomized mice].
    Author: Tordiia TV.
    Journal: Gematol Transfuziol; 1993 Feb; 38(2):7-10. PubMed ID: 8020724.
    Abstract:
    Age-specific trends in the number of early (CFUc-2 days) and late (CFUc-8 days) hemopoietic cell precursors were studied on the model of mature thymectomized (TE) mice. Bone marrow from TE mice derived at various postoperative intervals (4-100 weeks following thymectomy) was investigated against that from the control intact animals. It is shown that an increase in myelokaryocytes and absolute, but not relative, number of CFUc (CFUc-2 days and CFUc-8 days) was similar and age-related for both test and control animals. This fact evidences non-thymus-dependent regulation of CFUc content in the marrow. This conclusion can be also drawn from determination of CFUc sedimentation factor in the spleen of irradiated recipients. Lack of the thymus does not change CFUc ability to disseminate on the irradiated spleen.
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