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  • Title: Active and passive protection against variant and classic infectious bursal disease virus strains induced by baculovirus-expressed structural proteins.
    Author: Vakharia VN, Snyder DB, Lütticken D, Mengel-Whereat SA, Savage PK, Edwards GH, Goodwin MA.
    Journal: Vaccine; 1994 Apr; 12(5):452-6. PubMed ID: 8023554.
    Abstract:
    Infectious bursal disease virus (IBDV) is responsible for a highly immunosuppressive disease in young chickens which causes significant economic losses to the poultry industry worldwide. The structural protein genes (VP2, VP3 and VP4) of a variant IBDV strain (GLS) were expressed in insect cells using a baculovirus expression system. Susceptible chickens vaccinated with a single dose of the recombinant IBDV antigens were completely protected against challenge with two variant strains of IBDV (GLS and Delaware), and partially protected against the standard challenge strain (STC). A booster dose of the recombinant antigens induced higher levels of neutralizing antibodies and afforded complete protection against both variant and standard virus challenges. Specific-pathogen-free hens vaccinated with a single dose of the same subunit vaccine produced virus-neutralizing antibodies that were capable of passively protecting the progeny from infection with variant IBDV.
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