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  • Title: Hypocomplementemic urticarial vasculitis syndrome in identical twins.
    Author: Wisnieski JJ, Emancipator SN, Korman NJ, Lass JH, Zaim TM, McFadden ER.
    Journal: Arthritis Rheum; 1994 Jul; 37(7):1105-11. PubMed ID: 8024620.
    Abstract:
    Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a syndrome of recurrent urticarial vasculitis, arthralgia/arthritis, and hypocomplementemia. Angioedema, ocular inflammation, glomerulonephritis, and obstructive lung disease are other clinical findings. Although the etiology of HUVS is unknown, its resemblance to systemic lupus erythematosus (SLE) suggests a similar pathogenesis. SLE is known to occur in identical twins. This is the first report of a pair of identical twins with HUVS. Concordance for HUVS in identical twins suggests that the pathogenesis of the disease involves abnormal genetic immunoregulation.
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