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  • Title: A comparative study of the efficacy and toxicity of etodolac and naproxen in the treatment of osteoarthritis.
    Author: Chikanza IC, Clarke B, Hopkins R, MacFarlane DG, Bird H, Grahame R.
    Journal: Br J Clin Pract; 1994; 48(2):67-9. PubMed ID: 8024992.
    Abstract:
    In a two-period, double-blind, crossover study, patients with osteoarthritis of the knee and/or hip received etodolac 300 mg twice daily for 4 weeks and naproxen 500 mg twice daily for 4 weeks in random order. The assessment of efficacy showed that naproxen and etodolac were equally effective in the management of pain and stiffness in osteoarthritis. However, a significantly higher proportion of patients preferred naproxen to etodolac for the relief of pain intensity. The incidence of adverse events caused by either drug was the same.
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