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  • Title: The Cu/Zn superoxide dismutase gene in ALS and parkinsonism-dementia of Guam.
    Author: Figlewicz DA, Garruto RM, Krizus A, Yanagihara R, Rouleau GA.
    Journal: Neuroreport; 1994 Jan 31; 5(5):557-60. PubMed ID: 8025243.
    Abstract:
    Guam is one of three endemic foci whose indigenous (Chamorro) people have an unusually high incidence of fatal neurodegenerative disorders, amyotrophic lateral sclerosis (ALS) and Parkinsonism-dementia (PD). Recently, mutations in the Cu/Zn superoxide dismutase (SOD-1) gene have been identified in some familial cases of ALS. To investigate if mutations in the SOD-1 gene are also involved in the pathogenesis of ALS and PD of Guam, we analyzed the SOD-1 gene in Chamorros. No mutations were found in Chamorros with ALS or PD, indicating that mutations in the SOD-1 gene do not underlie the high-incidence neurodegenerative disorders of Guam.
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