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Title: Accelerated growth of mammary tumor cells in normal and athymic mice after treatment in vitro with dexamethasone. Author: Gillette RW, Wunderlich DA. Journal: Cancer Res; 1978 Oct; 38(10):3146-9. PubMed ID: 80260. Abstract: The tumorigenicity of dexamethasone-treated tissue-cultured mammary tumor cells was compared to that of untreated mammary tumor cells. The dexamethasone-induced cells progressed faster in normal syngeneic animals than did untreated mammary tumor cells. The fact that the growth rate differential was also observed in athymic mice suggests that T-lymphocyte-mediated immunity was not a factor in the accelerated progression in vivo of the tumor cells that had been cultured in the presence of dexamethasone.[Abstract] [Full Text] [Related] [New Search]