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  • Title: Angiotensins induce the release of prostacyclin from rabbit vas deferens: evidence for receptor heterogeneity.
    Author: Catalioto RM, Renzetti AR, Criscuoli M, Mizrahi J, Subissi A.
    Journal: Eur J Pharmacol; 1994 Apr 11; 256(1):93-7. PubMed ID: 8026565.
    Abstract:
    Angiotensin II and angiotensin III stimulated prostacyclin release in a time- and dose-dependent manner in both the prostatic and the non-prostatic part of the rabbit vas deferens. Also, angiotensin I enhanced the production of prostacyclin and its effect was blocked by captopril. Losartan, a type 1 (angiotensin AT1)-selective receptor antagonist, prevented the angiotensin II-induced prostacyclin release. The agonist peptide, p-aminophenylalanine angiotensin II, and the type 2 (angiotensin AT2)-selective receptor antagonist, PD123319, were found active only in the prostatic portion, suggesting heterogeneity of the receptor population. In conclusion, an angiotensin AT1 receptor mostly mediates the angiotensin-induced release of prostacyclin in the rabbit vas deferens.
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