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  • Title: The mechanism of chlorpromazine-induced red blood cell swelling.
    Author: Cornelius AS, Reilly MP, Suzuki M, Asakura T, Horiuchi K.
    Journal: Gen Pharmacol; 1994 Jan; 25(1):205-10. PubMed ID: 8026707.
    Abstract:
    1. Chlorpromazine (CPZ)-induced red blood cell (RBC) swelling was investigated by determination of electrolyte, mean cell volume (MCV) and water content changes in CPZ-treated cells. 2. CPZ-induced RBC swelling is dose-, hematocrit- and pH-dependent, and is associated with a net increase in RBC monovalent cation and Cl- contents. 3. The partition coefficient (Kp) for the CPZ-RBC membrane interaction is pH dependent (Kp = 2500 at pH 7.8; Kp = 840 at pH 6.8). 4. Despite the pH dependence of Kp values an equal number of CPZ molecules is required to induce a 12% increase in MCV at pH 7.8 and 6.8.
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